Virulence determinants of pandemic influenza viruses
نویسندگان
چکیده
منابع مشابه
Virulence determinants of pandemic influenza viruses.
Influenza A viruses cause recurrent, seasonal epidemics and occasional global pandemics with devastating levels of morbidity and mortality. The ability of influenza A viruses to adapt to various hosts and undergo reassortment events ensures constant generation of new strains with unpredictable degrees of pathogenicity, transmissibility, and pandemic potential. Currently, the combination of fact...
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To date there is no rapid method to screen for highly pathogenic avian influenza strains that may be indicators of future pandemics. We report here the first development of an oligonucleotide-based spectroscopic assay to rapidly and sensitively detect a N66S mutation in the gene coding for the PB1-F2 protein associated with increased virulence in highly pathogenic pandemic influenza viruses. 5'...
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Pandemic influenza viruses cause significant mortality in humans. In the 20th century, 3 influenza viruses caused major pandemics: the 1918 H1N1 virus, the 1957 H2N2 virus, and the 1968 H3N2 virus. These pandemics were initiated by the introduction and successful adaptation of a novel hemagglutinin subtype to humans from an animal source, resulting in antigenic shift. Despite global concern reg...
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The outcome of viral infections depends on a complex set of interactions between the viruses and their hosts. Particularly, viral infection triggers specific signaling programs within the infected cells that results in substantial changes in host gene expression. While some of these changes might be beneficial for viral replication, others represent the induction of a host antiviral response. I...
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pandemic influenza Necla Akçakaya, Ömer Kılıç, Yildiz Camcıoğlu, Haluk Çokuğraş, Kenan Midilli Department of Pediatrics, Division of Infectious Diseases, Clinical Immunology and Allergy, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Department of Microbiology and Clinical Microbiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Correspondence: Ömer K...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2011
ISSN: 0021-9738
DOI: 10.1172/jci44947